HCID 69093566, compound → HCID 86665517, compound

HRID 1770697Notes

Reaction equation

HRID 1770697 reaction equation
[C:1]([O:4][CH2:5][CH:6]([O:27][C:28](=[O:30])[CH3:29])[CH2:7][S:8]([CH2:11][CH2:12][C:13]([NH:16]C(OCC1C=CC=CC=1)=O)([CH3:15])[CH3:14])(=[O:10])=[O:9])(=[O:3])[CH3:2]>CO.[Pd]>[C:1]([O:4][CH2:5][CH:6]([O:27][C:28](=[O:30])[CH3:29])[CH2:7][S:8]([CH2:11][CH2:12][C:13]([NH2:16])([CH3:15])[CH3:14])(=[O:9])=[O:10])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 69093566HCID 69093566, compound

Product 1

HCID 86665517HCID 86665517, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 3-(3-(benzyloxycarbonylamino)-3-methylbutylsulfonyl)propane-1,2-diyl diacetate (401.9 mg, 0.9062 mmol) in methanol (10 ml) was added palladium on carbon (10%, 45 mg). The solution was purged with nitrogen gas, and then the suspension was put under a blanket of hydrogen gas (1.3 atm). The suspension was stirred for 1.5 hours, filtered through a 0.45 um PTFE filter, and concentrated in vacuo. The residue was used without any further purification. LRMS (ESI/APCI) m/z 310 [M+H]+.

Workup

  1. customThe solution was purged with nitrogen gas
  2. filtrationfiltered through a 0.45 um PTFE
  3. filtrationfilter
  4. concentrationconcentrated in vacuo
  5. customThe residue was used without any further purification

Sources & evidence

ORD record
ord-f4679199ad7341e88d663816478b6b42
Source dataset
uspto-grants-2016_02
Patent number
US09248117B2

Reaction notes

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