HCID 67517747, compound → HCID 86665533, compound

HRID 1770717Notes

Reaction equation

HRID 1770717 reaction equation
[C:1]([O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][S:14]([CH2:17][CH2:18][C:19]([NH:22]C(=O)OCC1C=CC=CC=1)([CH3:21])[CH3:20])(=[O:16])=[O:15])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][S:14]([CH2:17][CH2:18][C:19]([CH3:21])([NH2:22])[CH3:20])(=[O:16])=[O:15])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 67517747HCID 67517747, compound

Product 1

HCID 86665533HCID 86665533, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of benzyl 4-(2-(2-(2-tert-butoxyethoxy)ethoxy)ethylsulfonyl)-2-methylbutan-2-ylcarbamate (79.5 mg, 0.168 mmol) in MeOH (2 ml) was put under a N2 atmosphere and 10% Pd/C (30 mg) was added. A H2 atmosphere (1.3 atm) was added, and the slurry stirred for 2 h. The suspension was filtered (0.45 um PTFE) and the solution concentrated in vacuo. The residue was used without further purification. LRMS (ESI/APCI): 340 [M+H]+.

Workup

  1. additionA H2 atmosphere (1.3 atm) was added
  2. filtrationThe suspension was filtered (0.45 um PTFE)
  3. concentrationthe solution concentrated in vacuo
  4. customThe residue was used without further purification

Sources & evidence

ORD record
ord-93869485c1b841aabfd6275830f88daa
Source dataset
uspto-grants-2016_02
Patent number
US09248117B2

Reaction notes

Loading…