HCID 67509654, compound → HCID 86665534, compound

HRID 1770719Notes

Reaction equation

HRID 1770719 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][S:12]([CH2:15][CH2:16][C:17]([NH:20]C(=O)OCC1C=CC=CC=1)([CH3:19])[CH3:18])(=[O:14])=[O:13])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][S:12]([CH2:15][CH2:16][C:17]([CH3:19])([NH2:20])[CH3:18])(=[O:14])=[O:13])[CH3:2]

Participants

4

Reactant 1

HCID 67509654HCID 67509654, compound

Product 1

HCID 86665534HCID 86665534, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of benzyl 4-(2-(2-(2-ethoxyethoxy)ethoxy)ethylsulfonyl)-2-methylbutan-2-ylcarbamate (119.8 mg, 0.2691 mmol) in MeOH (3 ml) was put under N2 and 10% Pd/C (12.6 mg) was added. The vessel was pressurized with H2 (1.3 atm) and the suspension stirred vigorously for 1.5 h. The suspension was filtered through a PTFE (0.45 um) filter and concentrated in vacuo, and the residue used without any further purification. LRMS (ESI/APCI): 312 [M+H]+.

Workup

  1. filtrationThe suspension was filtered through a PTFE (0.45 um)
  2. filtrationfilter
  3. concentrationconcentrated in vacuo
  4. customthe residue used without any further purification

Sources & evidence

ORD record
ord-dc19454591444ec1b2e420c56f6dd23f
Source dataset
uspto-grants-2016_02
Patent number
US09248117B2

Reaction notes

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