HCID 67508302, compound → HCID 86665536, compound

HRID 1770724Notes

Reaction equation

HRID 1770724 reaction equation
[CH3:1][C:2]([NH:22]C(=O)OCC1C=CC=CC=1)([CH2:4][CH2:5][S:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH3:21])(=[O:8])=[O:7])[CH3:3]>CO>[CH3:3][C:2]([NH2:22])([CH2:4][CH2:5][S:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH3:21])(=[O:8])=[O:7])[CH3:1]

Participants

3

Reactant 1

HCID 67508302HCID 67508302, compound

Product 1

HCID 86665536HCID 86665536, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of benzyl 2-methyl-4-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethylsulfonyl)butan-2-ylcarbamate (6.07 g, 12.8 mmol) was dissolved in methanol (150 ml) was purged with N2. 10% palladium on carbon (890 mg) was added, and the suspension was put under a H2 (1.3 atmospheres) atmosphere. The suspension was stirred for 5 hours, filtered through Celite, and the solution concentrated in vacuo. The material was used without further purification. LRMS (ESI/APCI): 342 [M+H]+.

Workup

  1. customwas purged with N2
  2. addition10% palladium on carbon (890 mg) was added
  3. filtrationfiltered through Celite
  4. concentrationthe solution concentrated in vacuo
  5. customThe material was used without further purification

Sources & evidence

ORD record
ord-ed2b82b2f5de45a3a6ec5bfedcb455dd
Source dataset
uspto-grants-2016_02
Patent number
US09248117B2

Reaction notes

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