反应详情

The product of Example 32 (2.6 g, 9 mmol) was dissolved in dichloromethane, and the mixture was cooled in an ice-water bath, then 48% hydrobromic acid (0.54 mL, 10 mmol) was added dropwise, after the addition was complete, it was reacted at room temperature for 16 hours. After that, water was added therein for separating, the aqueous phase was extracted with dichloromethane three times, then the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to give the target compound 2.7 g, yield: 87%.

1. temperaturethe mixture was cooled in an ice-water bath
2. additionafter the addition
3. customit was reacted at room temperature for 16 hours
4. customfor separating
5. extractionthe aqueous phase was extracted with dichloromethane three times
6. washwashed with saturated brine
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated