反应详情

A 4 M solution of hydrogen chloride in dioxane (35 mL; 0.14 mol) was added to the product of 1a (3.3 g; 9.5 mmol) and stirred until the oil dissolved with evolution of gas. After standing one hour, the solvent was evaporated and the residue was triturated with diethyl ether (4×20 mL); the oil solidified to a tan powder. The residue was filtered and dried overnight in a drying pistol at 50° C. and 13 mm Hg. 2.05 g (96%) product was obtained (tan powder).

1. dissolutiondissolved with evolution of gas
2. customthe solvent was evaporated
3. customthe residue was triturated with diethyl ether (4×20 mL)
4. filtrationThe residue was filtered
5. customdried overnight in a drying pistol at 50° C.