Hydrochloric Acid → HCID 72736583, compound

HRID 1771034Notes

Reaction equation

HRID 1771034 reaction equation
C([NH:8][CH2:9][C:10](=[O:22])[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[O:14])(OC(C)(C)C)=O.[ClH:23]>C(OCC)C>[ClH:23].[NH2:8][CH2:9][C:10](=[O:22])[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90034513HCID 90034513, compound

Product 1

HCID 72736583HCID 72736583, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

This compound was prepared from the product of 5b (4.20 g; 13.2 mmol), 2 M HCl in diethyl ether (7.5 mL; 15 mmol), and diethyl ether (50 mL) as described in Example 1 b. After evaporation of the solvent, the oily residue was triturated with diethyl ether (4×10 mL) and kept overnight in a freezer until it solidified into a pale tan solid. 1.90 g (57%) product was obtained after drying at 12 mm Hg and ambient temperature.

Workup

  1. customAfter evaporation of the solvent
  2. customthe oily residue was triturated with diethyl ether (4×10 mL)

Sources & evidence

ORD record
ord-a6ca8d569b3844aeae4404ecb29e9190
Source dataset
uspto-grants-2016_02
Patent number
US09249086B2

Reaction notes

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