Carbon Dioxide → caesium 5-(Cbz-amino)-4-oxopentanoate

Participants

Role	Name	HCID	Charge
Reactant	Carbon Dioxide	HCID 280	—
Reactant	Cesium carbonate	HCID 10796	—
Reactant	5-{[(Benzyloxy)carbonyl]amino}-4-oxopentanoic acid	HCID 11369104	—
Solvent	Water	HCID 962	—
Product	caesium 5-(Cbz-amino)-4-oxopentanoate	HCID 90034572	211.5%

Reaction Steps

5-(Cbz-amino)-4-oxopentanoic acid (2.66 g; 10.0 mmol) was added to a stirred solution of caesium carbonate (1.64 g; 5.0 mmol) in de-ionized water (40 mL). After the evolution of CO2 ceased, the mixture was frozen with liquid nitrogen and freeze-dried overnight. 4.2 g (˜100%) product was obtained (pale tan solid). The product was used in 8c without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249086B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-40192ca87cac4b138dd495c6b7af5122
Source note	uspto-grants-2016_02