Carbon Dioxide → caesium 5-(Cbz-amino)-4-oxopentanoate

HRID 1771040Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1771040
[C:1]([NH:11][CH2:12][C:13](=[O:19])[CH2:14][CH2:15][C:16]([OH:18])=[O:17])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C(=O)([O-])[O-].[Cs+:24].[Cs+].C(=O)=O>O>[C:1]([NH:11][CH2:12][C:13](=[O:19])[CH2:14][CH2:15][C:16]([O-:18])=[O:17])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[Cs+:24]

Komponenten

5

Edukt 3

HCID 280Carbon DioxideHCID 10796Cesium carbonateHCID 113691045-{[(Benzyloxy)carbonyl]amino}-4-oxopentanoic acid

Produkt 1

HCID 90034572caesium 5-(Cbz-amino)-4-oxopentanoateAusbeute 211,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

5-(Cbz-amino)-4-oxopentanoic acid (2.66 g; 10.0 mmol) was added to a stirred solution of caesium carbonate (1.64 g; 5.0 mmol) in de-ionized water (40 mL). After the evolution of CO2 ceased, the mixture was frozen with liquid nitrogen and freeze-dried overnight. 4.2 g (˜100%) product was obtained (pale tan solid). The product was used in 8c without further purification.

Aufarbeitung

  1. temperaturethe mixture was frozen with liquid nitrogen
  2. customfreeze-dried overnight

Quellen und Nachweise

ORD-Eintrag
ord-40192ca87cac4b138dd495c6b7af5122
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09249086B2

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