HCID 89474285, compound → HCID 89462331, compound

HRID 1771122Notes

Reaction equation

HRID 1771122 reaction equation
[F:1][C:2]1[C:7]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[N:13]3)=[O:9])=[C:6]([F:20])[CH:5]=[CH:4][C:3]=1[NH:21]C(=O)OC(C)(C)C>CO>[NH2:21][C:3]1[C:2]([F:1])=[C:7]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[N:13]3)=[O:9])[C:6]([F:20])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 89474285HCID 89474285, compound

Product 1

HCID 89462331HCID 89462331, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of tert-butyl (2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)carbamate (600 mg, 1.56 mmol, 1 eq.) in HO/MeOH (6 N, 50 mL) was stirred at rt for 3 h, then concentrated to provide crude (3-amino-2,6-difluorophenyl) (quinoxalin-6-yl)methanone which was used in the next step without further purification.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-77baba7c865a4f68837d3ec031a4a942
Source dataset
uspto-grants-2016_02
Patent number
US09249110B2

Reaction notes

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