Glyoxal, phenyl-, hydrate → 3-(Methylthio)-5-phenyl-1,2,4-triazine

HRID 1771290Notes

Reaction equation

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].O.[C:8]1([C:14]([CH:16]=O)=O)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:16]=[C:14]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]=1

Participants

Reactant 2

HCID 12215922Glyoxal, phenyl-, hydrate

HCID 178504051Methyl hydrazinecarbimidothioate

Product 1

HCID 985413-(Methylthio)-5-phenyl-1,2,4-triazineYield 73.2%

Procedure

3-(Methylsulfanyl)-5-phenyl-1,2,4-triazine (2.93 g, 73%) was prepared from methyl hydrazinecarbimidothioate (2.07 g, 19.7 mmol) and phenylglyoxal monohydrate (2.89 g, 19.7 mmol) according to the general procedure of Preparation 2.

Workup

customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record: ord-1f4678adfd4845d08fa001dbeb60a397
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249130B2

Reaction notes

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