Ammonia → HCID 43134547, compound

HRID 1771293Notes

Reaction equation

HRID 1771293 reaction equation
CS([C:5]1[N:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])[N:10]=1)(=O)=O.[NH3:19].C1COCC1>>[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:9]1[N:10]=[C:5]([NH2:19])[N:6]=[N:7][CH:8]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 67362659HCID 67362659, compound

Product 1

HCID 43134547HCID 43134547, compoundYield 53%

Procedure

5-(2,4-Difluorophenyl)-1,2,4-triazin-3-amine (0.45 g, 53%) was prepared from 3-(methylsulfonyl)-5-(2,4-difluorophenyl)-1,2,4-triazine (1.10 g, 4.05 mmol) and 0.5 M ammonia in THF (50 mL, 25 mmol) according to the general procedure of Preparation 2.

Workup

  1. customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record
ord-24945a6e451444759227503a8c42f8d7
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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