Ammonia → HCID 67362885, compound

HRID 1771299Notes

Reaction equation

HRID 1771299 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12](S(C)(=O)=O)[N:13]=[N:14][CH:15]=2)=[CH:6][CH:5]=1.[NH3:20]>C1COCC1>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH2:20])[N:13]=[N:14][CH:15]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67365040HCID 67365040, compound

Product 1

HCID 67362885HCID 67362885, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-[4-(methoxymethyl)phenyl]-1,2,4-triazin-3-amine (2.2 g, 85%) was prepared from 5-[4-(methoxymethyl)phenyl]-3-(methylsulfonyl)-1,2,4-triazine (3.40 g, 12.2 mmol) in THF (35 mL) and treated with NH3 gas by purging for 30 minutes, similarly to the general procedure of Preparation 2.

Workup

  1. customby purging for 30 minutes, similarly to the general procedure of Preparation 2

Sources & evidence

ORD record
ord-3b4cde55f0d34ed4944c6485cb048c8a
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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