4-Fluorophenylboronic acid → 6-(4-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine

HRID 1771313Notes

Reaction equation

HRID 1771313 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 673636766-(4-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amineYield 46.5%

Procedure

6-(4-Fluorophenyl)-5-phenyl-1,2,4-triazin-3-amine (99 mg, 46%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.80 mmol) and 4-fluorophenylboronic acid (0.112 g, 0.80 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-4ed496f5542542f1b6b66d61edc587ee
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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