Azetidine → HCID 53354625, compound

HRID 1771387Notes

Reaction equation

[C:1]1([C:7]2[N:8]=[C:9]([NH2:24])[N:10]=[N:11][C:12]=2[C:13]2[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[N:16]=[C:15](Cl)[CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:25]1[CH2:28][CH2:27][CH2:26]1>>[N:25]1([C:15]2[CH:14]=[C:13]([C:12]3[N:11]=[N:10][C:9]([NH2:24])=[N:8][C:7]=3[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[N:16]=2)[CH2:28][CH2:27][CH2:26]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 86676123HCID 86676123, compound

Product 1

HCID 53354625HCID 53354625, compoundYield 19%

Procedure

6-[2-(Azetidin-1-yl)-6-(trifluoromethyl)pyridin-4-yl]-5-phenyl-1,2,4-triazin-3-amine (20.0 mg, 19%) was prepared from 5-phenyl-6-(2-chloro-6-trifluoromethyl-pyridin-4-yl)-1,2,4-triazin-3-amine (100 mg, 0.28 mmol) and azetidine according to the general procedure for Preparation 4a.

Sources & evidence

ORD record: ord-2c57b8d3537b4a0a89aeb77361d59f58
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249130B2

Reaction notes

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