Chlorotrimethylsilane → HCID 89852940, compound

HRID 1771407Notes

Reaction equation

HRID 1771407 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][O:6][CH:7]2[C:12]([OH:14])=[O:13].[CH3:15][Si](Cl)(C)C>CO>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][O:6][CH:7]2[C:12]([O:14][CH3:15])=[O:13]

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 55250755HCID 55250755, compound

Product 1

HCID 89852940HCID 89852940, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of 5-methylisochroman-1-carboxylic acid (1 g), methanol (20 ml) and trimethylsilylchloride (2 ml) was stirred for 1.5 hrs and volatiles evaporated. Separation method E yielded the title compound (0.5 g) as yellowish oil. Alternatively sulphuric acid can be used instead of trimethylsilylchloride.

Workup

  1. customvolatiles evaporated
  2. customSeparation method E

Sources & evidence

ORD record
ord-08bfca2cdd824fabb897ded7ea71b51c
Source dataset
uspto-grants-2016_02
Patent number
US09249127B2

Reaction notes

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