Aluminum(III) Chloride → HCID 89852398, compound

HRID 1771427Notes

Reaction equation

HRID 1771427 reaction equation
[Br:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][CH2:5][S:6][CH:7](Cl)[C:8]([O:10][CH3:11])=[O:9].[Cl-].[Cl-].[Cl-].[Al+3]>C(Cl)Cl>[CH3:11][O:10][C:8]([CH:7]1[C:13]2[C:3](=[C:2]([Br:1])[CH:16]=[CH:15][CH:14]=2)[CH2:4][CH2:5][S:6]1)=[O:9]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 89852317HCID 89852317, compound

Product 1

HCID 89852398HCID 89852398, compoundYield 69.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of methyl 2-((2-bromophenethyl)thio)-2-chloroacetate (4.7 g), aluminum trichloride (2 g) and DCM (15 ml) was stirred in ice bath and allowed to warm up to ambient temperature and stirred 3.5 hrs. Separation method B and E yielded the title compound (2.9 g).

Workup

  1. stirringstirred 3.5 hrs
  2. customSeparation method B and E

Sources & evidence

ORD record
ord-f8fff554b22547bda12cfadc2fa35fcd
Source dataset
uspto-grants-2016_02
Patent number
US09249127B2

Reaction notes

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