HCID 89851907, compound → HCID 89851705, compound

HRID 1771442Notes

Reaction equation

HRID 1771442 reaction equation
C([O:8][CH:9]([CH2:18][CH2:19][F:20])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17])C1C=CC=CC=1>CO.[Pd]>[F:20][CH2:19][CH2:18][CH:9]([OH:8])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17]

Participants

4

Reactant 1

HCID 89851907HCID 89851907, compound

Product 1

HCID 89851705HCID 89851705, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1-(2-(benzyloxy)-4-fluorobutyl)-2-methylbenzene (3.0 g, 11.03 mmol) in MeOH (50 ml) was added 10% Pd/C (0.3 g) under nitrogen and stirred at 40 psi for 5 h. The reaction mixture was filtered through Celite and concentrated under reduced pressure to afford crude compound. The title compound was purified by separation method E. (Yield 1.5 g).

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationconcentrated under reduced pressure
  3. customto afford crude compound
  4. customThe title compound was purified by separation method E

Sources & evidence

ORD record
ord-7ef99682770f4d539486b971400579c3
Source dataset
uspto-grants-2016_02
Patent number
US09249127B2

Reaction notes

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