HCID 89851713, compound → HCID 89851565, compound

HRID 1771443Notes

Reaction equation

HRID 1771443 reaction equation
C([O:8][CH:9]([CH2:18][CH:19]([F:21])[F:20])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17])C1C=CC=CC=1>CO.[Pd]>[F:20][CH:19]([F:21])[CH2:18][CH:9]([OH:8])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17]

Participants

4

Reactant 1

HCID 89851713HCID 89851713, compound

Product 1

HCID 89851565HCID 89851565, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1-(2-(benzyloxy)-4,4-difluorobutyl)-2-methylbenzene (10 g, 34.48 mmol) in MeOH (150 ml) was added 10% Pd/C (1.0 g) under nitrogen and stirred at 40 psi for 5 h. The reaction mixture was filtered through Celite and concentrated under reduced pressure to afford crude compound. The title compound was purified by separation method E. (Yield 6.0 g).

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationconcentrated under reduced pressure
  3. customto afford crude compound
  4. customThe title compound was purified by separation method E

Sources & evidence

ORD record
ord-a3707b960dab460680ea63073e7bc118
Source dataset
uspto-grants-2016_02
Patent number
US09249127B2

Reaction notes

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