(6-Hydroxynaphthalen-2-yl)boronic acid → HCID 136069515, compound

HRID 1771457Notes

Reaction equation

HRID 1771457 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7](B(O)O)[CH:6]=[CH:5]2.Cl[C:16]1[N:21]=[N:20][C:19]([C:22]([O:24]C)=[O:23])=[CH:18][CH:17]=1>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:16]1[N:21]=[N:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 4349738(6-Hydroxynaphthalen-2-yl)boronic acidHCID 12379801Methyl 6-chloropyridazine-3-carboxylate

Product 1

HCID 136069515HCID 136069515, compound

Procedure

Followed the two step procedure described for Example 7 starting from 6-hydroxynaphthalen-2-ylboronic acid and methyl 6-chloropyridazine-3-carboxylate. 1H-NMR (DMSO-d6 500 MHz): 10.16 (s, 1H), 8.71 (d, J=5.0 Hz, 1H), 8.51-8.48 (m, 1H), 8.30-8.23 (m, 2H), 7.97-7.86 (m, 2H), 7.23-7.19 (m, 2H). MS (ESI): m/z 267.0 [M+1]+.

Sources & evidence

ORD record
ord-fe0770c10b8a476abc84b21c604f59ff
Source dataset
uspto-grants-2016_02
Patent number
US09249132B2

Reaction notes

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