(6-Hydroxynaphthalen-2-yl)boronic acid → HCID 57386908, compound

HRID 1771460Notes

Reaction equation

HRID 1771460 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7](B(O)O)[CH:6]=[CH:5]2.Br[C:16]1[CH:17]=[N:18][C:19]([C:22]([O:24]C)=[O:23])=[N:20][CH:21]=1>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:16]1[CH:17]=[N:18][C:19]([C:22]([OH:24])=[O:23])=[N:20][CH:21]=1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 4349738(6-Hydroxynaphthalen-2-yl)boronic acidHCID 45790831Methyl 5-bromopyrimidine-2-carboxylate

Product 1

HCID 57386908HCID 57386908, compound

Procedure

Followed the two step procedure described for Example 7 starting from 6-hydroxynaphthalen-2-yl boronic acid and methyl 5-bromopyrimidine-2-carboxylate. 1H-NMR (DMSO-d6 500 MHz): 9.39 (s, 2H), 8.38 (s, 1H), 7.87-7.91 (t, J=8.5, 12.0 Hz, 3H), 7.17-7.20 (t, J=5.5, 10.5 Hz, 2H). MS (ESI): m/z=267.0 [M+1]+.

Sources & evidence

ORD record
ord-f29cc054e385492d98cc6b578c5c041c
Source dataset
uspto-grants-2016_02
Patent number
US09249132B2

Reaction notes

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