反应详情

To a solution of trichloropyrimidine (5.04 g, 27.3 mol) in DCM (50 mL) cooled to 0° C. was added DIPEA (4.79 mL, 27.3 mol), followed by 3-(S)-methylmorpholine (3.11 g, 30.5 mol) dropwise. The reaction mixture was allowed to warm to RT and stirred for 3 h wherupon it was diluted with DCM, washed with water and brine, dried over magnesium sulfate, filtered and the solvent removed in vacuo. The residue was purified by flash chromatography (5-10% EtOAc in petroleum ether (40-60)) to yield the two isomers.

1. washwashed with water and brine
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered
4. customthe solvent removed in vacuo
5. customThe residue was purified by flash chromatography (5-10% EtOAc in petroleum ether (40-60))
6. customto yield the two isomers