2-Fluoroethylamine → 1-(2-Fluoroethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

HRID 1771532Notes

Reaction equation

HRID 1771532 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([B:16]3[O:20][C:19]([CH3:22])([CH3:21])[C:18]([CH3:24])([CH3:23])[O:17]3)=[CH:12][CH:11]=2)C=CC=CC=1.[F:26][CH2:27][CH2:28][NH2:29]>>[F:26][CH2:27][CH2:28][NH:29][C:8]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([B:16]2[O:17][C:18]([CH3:23])([CH3:24])[C:19]([CH3:22])([CH3:21])[O:20]2)=[CH:12][CH:11]=1)=[O:7]

Participants

3

Reactant 2

HCID 99962-FluoroethylamineHCID 58885831Phenyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate2×

Product 1

HCID 446073531-(2-Fluoroethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Procedure

Method as described for intermediate 13 using phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (intermediate 17) and 2-fluoroethylamine to afford a pink wax (3.8 g) used without further purification.

Workup

  1. customto afford a pink wax (3.8 g)
  2. customused without further purification

Sources & evidence

ORD record
ord-69e6082ea8d7460989050d2c2d64e145
Source dataset
uspto-grants-2016_02
Patent number
US09249129B2

Reaction notes

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