2-(Methylsulfonyl)phenylboronic Acid → 1-Ethyl-3-(4-(6-(2-(methylsulfonyl)phenyl)-2-morpholinopyrimidin-4-yl)phenyl)urea

Participants

Reaction Steps

Method as described for Example 8 using 1-(4-(6-chloro-2-morpholinopyrimidin-4-yl)phenyl)-3-ethylurea and (2-methylsulfonylphenyl)boronic acid. The reaction mixture was concentrated in vacuo, and the residue dissolved in DMSO, filtered and purified by prep HPLC (low pH) to afford a white solid (13.2 mg, 10%).

Provenance & Evidence