Morpholine → 1-(4-(4-Morpholinopyrimidin-2-yl)phenyl)-3-propylurea

HRID 1771550Notes

Reaction equation

HRID 1771550 reaction equation
[CH2:1]([NH:4][C:5](=[O:22])[NH:6][C:7]1[CH:12]=[CH:11][C:10](B2OC(C)(C)C(C)(C)O2)=[CH:9][CH:8]=1)[CH2:2][CH3:3].Cl[C:24]1[N:29]=[C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[CH:27]=[CH:26][N:25]=1.N1CCOCC1>>[O:33]1[CH2:34][CH2:35][N:30]([C:28]2[CH:27]=[CH:26][N:25]=[C:24]([C:10]3[CH:9]=[CH:8][C:7]([NH:6][C:5]([NH:4][CH2:1][CH2:2][CH3:3])=[O:22])=[CH:12][CH:11]=3)[N:29]=2)[CH2:31][CH2:32]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 17146974-(2-Chloropyrimidin-4-yl)morpholineHCID 441195781-Propyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Product 1

HCID 533807451-(4-(4-Morpholinopyrimidin-2-yl)phenyl)-3-propylurea

Procedure

Method as described for Example 34 using (4-(3-propylureido)phenyl)boronic acid pinacol ester and 4-(2-chloropyrimidin-4-yl)morpholine which was synthesised according to Intermediate 3, using morpholine as starting material.

Workup

  1. customwas synthesised

Sources & evidence

ORD record
ord-726fcf0bbe73493c9e5d29463d1eb0bc
Source dataset
uspto-grants-2016_02
Patent number
US09249129B2

Reaction notes

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