HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Ethyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea → (S)-1-ethyl-3-(4-(2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Ethyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea | HCID 44119377 | — |
| Reactant | (S)-4-(6-(5-fluoropyridin-3-yl)-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine | HCID 67382782 | — |
| Reactant | (S)-4-(4-chloropyrimidin-2-yl)-3-methylmorpholine | HCID 87379247 | — |
| Product | (S)-1-ethyl-3-(4-(2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)urea | HCID 53380859 | — |
Reaction Steps
Method as described for intermediate 5 using (S)-4-(4-chloropyrimidin-2-yl)-3-methylmorpholine (intermediate 15) and 4-(3-ethylureido)phenyl boronic acid pinacol ester. Material was purified by prep HPLC (low pH) to afford a brown solid, (77 mg, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249129B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-521b90b51ac44693a03b392f5634143d |
| Source note | uspto-grants-2016_02 |