HRID1771562

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID72942067

未命名化合物

2 次

结构：CC1(C)OB(c2ccc(NC(=O)NCC(F)F)cc2)OC1(C)C

HCID86691147

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H]1COCCN1c1ccnc(-c2ccc(NC(=O)NCC(F)F)cc2)n1

HCID53379664

未命名化合物

PROCEDURE

实验过程

Method as described for example 49 using (S)-4-(2-chloropyrimidin-4-yl)-3-methylmorpholine (intermediate 3) and 1-(2,2-difluoroethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (intermediate 20). Purified by prep HPLC at high pH to afford the title compound. (68 mg, 38%).

WORKUP

后处理

customPurified by prep HPLC at high pH