HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-(2-Chloropyrimidin-4-yl)-3-methylmorpholine → (S)-1-(2,2-difluoroethyl)-3-(4-(4-(3-methylmorpholino)pyrimidin-2-yl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-(2-Chloropyrimidin-4-yl)-3-methylmorpholine | HCID 72942067 | — |
| Reactant | 1-(2,2-Difluoroethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea | HCID 86691147 | — |
| Product | (S)-1-(2,2-difluoroethyl)-3-(4-(4-(3-methylmorpholino)pyrimidin-2-yl)phenyl)urea | HCID 53379664 | — |
Reaction Steps
Method as described for example 49 using (S)-4-(2-chloropyrimidin-4-yl)-3-methylmorpholine (intermediate 3) and 1-(2,2-difluoroethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (intermediate 20). Purified by prep HPLC at high pH to afford the title compound. (68 mg, 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249129B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-a85d9ece82784979a1b9089c5455de59 |
| Source note | uspto-grants-2016_02 |