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HRID1771567

反应详情

EQUATION

反应方程式

HRID 1771567 的结构方程式

REACTANTS

反应物

3
结构：CSc1nc(Cl)cc(Cl)n1
HCID80531

4,6-Dichloropyrimidine methyl sulphide

C5H4Cl2N2S

结构：CSc1ccc(F)cc1B(O)O
HCID53216369

[5-Fluoro-2-(methylsulfanyl)phenyl]boronic acid

C7H8BFO2S

结构：CSc1nc(-c2cncc(F)c2)cc(N2CCOC[C@@H]2C)n1
HCID67382782

未命名化合物

PRODUCTS

生成物

1
结构：CSc1nc(Cl)cc(-c2cc(F)ccc2SC)n1
HCID86691154

未命名化合物

PROCEDURE

实验过程

Method as described for intermediate 5 using 4,6-dichloro-2-(methylthio)pyrimidine and 5-fluoro-2-(methylthio)phenylboronic acid. The residue was purified further by flash chromatography (0-10% EtOAc in petroleum ether (40:60) to afford 4-chloro-6-(5-fluoro-2-(methylthio)phenyl)-2-(methylthio)pyrimidine as a white solid, (500 mg, 42%)

WORKUP

后处理

  1. customThe residue was purified further by flash chromatography (0-10% EtOAc in petroleum ether (40:60)