4,6-Dichloro-2-(methylthio)pyrimidine → 4-Chloro-6-(5-fluoro-2-(methylthio)phenyl)-2-(methylthio)pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	4,6-Dichloro-2-(methylthio)pyrimidine	HCID 80531	—
Reactant	5-Fluoro-2-(methylthio)phenylboronic acid	HCID 53216369	—
Reactant	(S)-4-(6-(5-fluoropyridin-3-yl)-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine	HCID 67382782	—
Product	4-Chloro-6-(5-fluoro-2-(methylthio)phenyl)-2-(methylthio)pyrimidine	HCID 86691154	—

Reaction Steps

Method as described for intermediate 5 using 4,6-dichloro-2-(methylthio)pyrimidine and 5-fluoro-2-(methylthio)phenylboronic acid. The residue was purified further by flash chromatography (0-10% EtOAc in petroleum ether (40:60) to afford 4-chloro-6-(5-fluoro-2-(methylthio)phenyl)-2-(methylthio)pyrimidine as a white solid, (500 mg, 42%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249129B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-cbbe021f6c064c1b81a9cdd560c897b9
Source note	uspto-grants-2016_02