反应详情

Method as described for example 58 using (S)-phenyl(4-(6-(5-fluoro-2-(methylsulfonyl)phenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)carbamate)(intermediate 32) (100 mg, 0.18 mmol) and 2-amino-2-methylpropan-1-ol (24 mg, 0.27 mmol). The reaction mixture was purified by prep HPLC at low pH to afford the title compound as a yellow solid. (45 mg, 45%)

1. customThe reaction mixture was purified by prep HPLC at low pH