Cyclopropylamine → HCID 53380041, compound

HRID 1771584Notes

Reaction equation

HRID 1771584 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[N:21]=[C:20]([C:22]4[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=4[S:29]([CH3:32])(=[O:31])=[O:30])[CH:19]=[C:18]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][C@@H:34]4[CH3:39])[N:17]=3)=[CH:12][CH:11]=2)C=CC=CC=1.[CH:41]1([NH2:44])[CH2:43][CH2:42]1>>[CH:41]1([NH:44][C:8]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[N:21]=[C:20]([C:22]4[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=4[S:29]([CH3:32])(=[O:30])=[O:31])[CH:19]=[C:18]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][C@@H:34]4[CH3:39])[N:17]=3)=[CH:12][CH:11]=2)=[O:7])[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 68233577HCID 68233577, compound2×

Product 1

HCID 53380041HCID 53380041, compound

Procedure

Method as for example 58 using (S)-phenyl(4-(4-(5-fluoro-2-(methylsulfonyl)phenyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)carbamate (intermediate 34) and cyclopropyl amine as starting materials. The solvent removed in vacuo and the crude material purified by prep HPLC at low pH to yield the title compound.

Workup

  1. customThe solvent removed in vacuo
  2. customthe crude material purified by prep HPLC at low pH

Sources & evidence

ORD record
ord-0eb7c57d06df4c79be2f75f42eb45475
Source dataset
uspto-grants-2016_02
Patent number
US09249129B2

Reaction notes

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