反应详情

To a solution of tert-butyl N-(3-hydroxy-2,6-dimethyl-phenyl)carbamate (657 mg, 2.8 mmol, 1.0 eq) in DCM (5 mL) was added TFA (5 mL) and the reaction stirred at room temperature overnight. The solvent was removed in vacuo. The residue was taken up in water and solution adjusted to pH 7 by addition of aqueous NaHCO3. The aqueous phase was extracted with EtOAc and the organic extract dried (Na2SO4), filtered and evaporated in vacuo to give the title compound as a yellow solid (370 mg, 97%) which was used without further purification.

1. customThe solvent was removed in vacuo
2. additionsolution adjusted to pH 7 by addition of aqueous NaHCO3
3. extractionThe aqueous phase was extracted with EtOAc
4. extractionthe organic extract
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. customevaporated in vacuo