反应详情

To a solution of ethyl 2-[3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-dimethyl-phenoxy]acetate (300 mg, 0.71 mmol, 1.0 eq) in THF (8 mL) was added a solution of NaOH (1M aqueous solution, 3 mL, 3 mmol, 4.2 eq) at room temperature. The reaction mixture was stirred 1 h, then the THF was removed in vacuo. The remaining aqueous solution was poured into water and adjusted to pH 3 by addition of 1M HCl. The solid precipitate that formed was collected by filtration, washed with water and dried in vacuo to give the title compound (I(j)) as a solid (250 mg, 89%).

1. customthe THF was removed in vacuo
2. additionThe remaining aqueous solution was poured into water
3. additionadjusted to pH 3 by addition of 1M HCl
4. customThe solid precipitate that formed
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried in vacuo