反应详情

A solution of ethyl 2-[4-chloro-2-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate (80 mg, 0.18 mmol, 1.0 eq) in THF (6 mL) was added to a 1M solution of NaOH (2 mL, 2 mmol, 11.1 eq). The reaction mixture was stirred at room temperature for 2 h. The organic solvent was removed in vacuo and the aqueous solution diluted with water. The solution was adjusted to pH 3 by addition of diluted HCl and the precipitate that formed collected by filtration, washed with water and dried in vacuo to give the title compound (I(k)) as white solid (65 mg, 87%).

1. customThe organic solvent was removed in vacuo
2. additionthe aqueous solution diluted with water
3. additionThe solution was adjusted to pH 3 by addition of diluted HCl
4. customthe precipitate that formed
5. filtrationcollected by filtration
6. washwashed with water
7. customdried in vacuo