反应详情

To a solution of ethyl 2-[4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenoxy]acetate (200 mg, 0.466 mmol, 1.0 eq) in THF (8 mL) was added NaOH (1M aqueous solution, 4 mL, 4.0 mmol, 9.0 eq) at 0° C. The reaction mixture was stirred at room temperature for 1 h, then the organic solvent removed under reduced pressure and the aqueous solution diluted with water and adjusted to pH 4-6 by addition of diluted HCl. The precipitate that formed was collected by filtration, washed with water and dried in vacuo to give the title compound (I(m)) as a solid (150 mg, 80%).

1. customthe organic solvent removed under reduced pressure
2. additionthe aqueous solution diluted with water
3. additionadjusted to pH 4-6 by addition of diluted HCl
4. customThe precipitate that formed
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried in vacuo