反应详情

To a solution of methyl 3-(3-fluorophenyl)-5-methoxy-benzoate (3 g, 11.5 mmol, 1.0 eq) in a mixture of methanol (20 mL) and THF (20 mL) at 0° C. was added a solution of aqueous KOH (2M aqueous solution, 20 mL, 40 mmol, 3.5 eq). The reaction mixture was stirred at room temperature for 2 h. The resulting mixture was concentrated to remove the methanol and THF then poured into water and the pH adjusted to pH 3-4 by addition of 1M HCl. The precipitate that formed was collected by filtration, washed with water and dried in vacuo to give the title compound as a white solid (2.5 g, 88%).

1. concentrationThe resulting mixture was concentrated
2. customto remove the methanol and THF
3. additionthen poured into water
4. additionthe pH adjusted to pH 3-4 by addition of 1M HCl
5. customThe precipitate that formed
6. filtrationwas collected by filtration
7. washwashed with water
8. customdried in vacuo