反应详情

5-bromobenzene-1,3-dicarboxylic acid (5 g, 20.4 mmol, 1.0 eq) was dissolved in DMF (150 mL). Cs2CO3 (33.2 g, 102 mmol, 5.0 eq) was added and the reaction stirred for 30 min. MeI (7.2 g, 51 mmol, 2.5 eq) was added dropwise and the solution was stirred at room temperature overnight. Water was added and the aqueous layer was extracted with EtOAc. The combined organic extracts were dried (Na2SO4), filtered and evaporated in vacuo to give the title compound as a colourless oil (5 g, 90%).

1. stirringthe solution was stirred at room temperature overnight
2. extractionthe aqueous layer was extracted with EtOAc
3. dry with materialThe combined organic extracts were dried (Na2SO4)
4. filtrationfiltered
5. customevaporated in vacuo