反应详情

To a solution of isopropyl 2-[4-fluoro-3-[[3-(3-fluorophenyl)-5-hydroxy-phenyl]methylamino]-2-methyl-phenoxy]acetate (90 mg, 0.2 mmol, 1 eq) in a mixture of MeOH (3 mL) and THF (3 mL) was added NaOH (1 M aqueous solution, 3 mL, 3 mmol) and the reaction was stirred at room temperature for 3 h. The MeOH and THF were removed under reduced pressure and the aqueous phase was acidified to pH 3-6 by addition of 1M HCl. The aqueous layer was extracted with EtOAc and the combined organic extracts were dried (Na2SO4), filtered and evaporated in vacuo to give the title compound as yellow oil (30 mg, 37%).

1. customThe MeOH and THF were removed under reduced pressure
2. additionthe aqueous phase was acidified to pH 3-6 by addition of 1M HCl
3. extractionThe aqueous layer was extracted with EtOAc
4. dry with materialthe combined organic extracts were dried (Na2SO4)
5. filtrationfiltered
6. customevaporated in vacuo