反应详情

To a solution of isopropyl 2-[3-[[3-(3-fluorophenyl)-5-hydroxy-phenyl]methylamino]-2,4-dimethyl-phenoxy]acetate (100 mg, 0.22 mmol, 1.0 eq) in THF (10 mL) at 0° C. was added NaOH (1M aqueous solution, 3 mL, 3 mmol). The reaction mixture was stirred at room temperature overnight then the THF was removed under reduced pressure. The remaining aqueous solution was poured into water and adjusted to pH 4-6 by addition of diluted HCl. The solid that precipitated was collected by filtration, washed with water and dried in vacuo to give the title compound as a yellow solid (60 mg, 66%).

1. customthe THF was removed under reduced pressure
2. additionThe remaining aqueous solution was poured into water
3. additionadjusted to pH 4-6 by addition of diluted HCl
4. customThe solid that precipitated
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried in vacuo