反应详情

To a solution of isopropyl 2-[4-fluoro-3-[[5-(3-fluorophenyl)-2,3-dimethyl-phenyl]methylamino]-2-methyl-phenoxy]acetate (80 mg, 0.17 mmol, 1.0 eq) in a mixture of THF (5 mL) and MeOH (5 mL) was added NaOH (2M aqueous solution, 5 mL, 10 mmol). The reaction was stirred for 3 h then the organic solvent was removed under reduced pressure. The remaining aqueous solution was adjusted to pH 5 with diluted HCl and the mixture extracted with EtOAc. The combined organic extracts were dried (Na2SO4), filtered and evaporated in vacuo. The residue obtained was purified by column chromatography (CH2Cl2:MeOH, 400:1 to 4:1) to give the title compound as a white solid (74 mg, 97%).

1. customthe organic solvent was removed under reduced pressure
2. extractionthe mixture extracted with EtOAc
3. dry with materialThe combined organic extracts were dried (Na2SO4)
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe residue obtained
7. customwas purified by column chromatography (CH2Cl2:MeOH, 400:1 to 4:1)