3,6-Dimethyl-2-pyridinamine → HCID 178425974, compound

HRID 1771982Notes

Reaction equation

HRID 1771982 reaction equation
[C:1]1([CH3:14])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[S:9]([O:12][NH2:13])(=[O:11])=[O:10].[CH3:15][C:16]1[C:17]([NH2:23])=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=1>C(Cl)Cl>[NH2:13][N:18]1[C:19]([CH3:22])=[CH:20][CH:21]=[C:16]([CH3:15])[C:17]1=[NH2+:23].[CH3:8][C:3]1[CH:4]=[C:5]([CH3:7])[CH:6]=[C:1]([CH3:14])[C:2]=1[S:9]([O-:12])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 5789563,6-Dimethyl-2-pyridinamineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 178425974HCID 178425974, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of O-(mesitylsulfonyl)hydroxylamine (5.3 g, 24.6 mmol) in DCM (20 mL) was slowly added to a solution of 3,6-dimethylpyridin-2-amine (1.0 g, 8.2 mmol) in DCM (5 mL). A yellow precipitate was formed gradually, and after stirring for 1 h, the precipitate was collected by filtration and used for the next step without further purification. ESI MS: m/z 138 [M+H]+.

Workup

  1. customA yellow precipitate was formed gradually
  2. filtrationthe precipitate was collected by filtration
  3. customused for the next step without further purification

Sources & evidence

ORD record
ord-0c8a4440866e474caeeafb8e84ea9576
Source dataset
uspto-grants-2016_02
Patent number
US09249162B2

Reaction notes

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