2-Amino-3-methylpyridine → HCID 178425976, compound

HRID 1771986Notes

Reaction equation

HRID 1771986 reaction equation
[C:1]1([CH3:14])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[S:9]([O:12][NH2:13])(=[O:11])=[O:10].[NH2:15][C:16]1[C:21]([CH3:22])=[CH:20][CH:19]=[CH:18][N:17]=1>C(Cl)Cl>[NH2:13][N:17]1[CH:18]=[CH:19][CH:20]=[C:21]([CH3:22])[C:16]1=[NH2+:15].[CH3:8][C:3]1[CH:4]=[C:5]([CH3:7])[CH:6]=[C:1]([CH3:14])[C:2]=1[S:9]([O-:12])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 153472-Amino-3-methylpyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 178425976HCID 178425976, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of O-(mesitylsulfonyl)hydroxylamine (6.45 g, 30.0 mmol) in DCM (30 mL) was stirred at room temperature, then 2-amino-3-methylpyridine (1.08 g, 10.0 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 h, the solvent was removed under vacuum, and the crude product was used for the next step without further purification. ESI MS: m/z 124 [M+H]+.

Workup

  1. customthe solvent was removed under vacuum
  2. customthe crude product was used for the next step without further purification

Sources & evidence

ORD record
ord-014fc706645f40d2832b6bcf853743bc
Source dataset
uspto-grants-2016_02
Patent number
US09249162B2

Reaction notes

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