2,5-DIMETHYLPYRIMIDIN-4-AMINE → HCID 178425978, compound

HRID 1771992Notes

Reaction equation

HRID 1771992 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH3:9])=[CH:4][N:3]=1.[C:10]1([CH3:23])[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[C:11]=1[S:18]([O:21][NH2:22])(=[O:20])=[O:19]>C(Cl)Cl>[NH2:22][N:7]1[C:6](=[NH2+:8])[C:5]([CH3:9])=[CH:4][N:3]=[C:2]1[CH3:1].[CH3:17][C:12]1[CH:13]=[C:14]([CH3:16])[CH:15]=[C:10]([CH3:23])[C:11]=1[S:18]([O-:21])(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 4457792,5-DIMETHYLPYRIMIDIN-4-AMINEHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 178425978HCID 178425978, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2,5-dimethylpyrimidin-4-amine (15.2 g, 49.0 mmol) in DCM (30 in L) was stirred at room temperature, and O-(mesitylsulfonyl)hydroxylamine (2.0 g, 16.0 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 h, then the solvent was removed under reduced pressure. The crude product was used for the next step without further purification. ESI MS: m/z 139 [M+H]+.

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 12 h
  2. customthe solvent was removed under reduced pressure
  3. customThe crude product was used for the next step without further purification

Sources & evidence

ORD record
ord-23017523cac74a77a791a1ed72f6b13c
Source dataset
uspto-grants-2016_02
Patent number
US09249162B2

Reaction notes

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