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0 °C

To trifluoroacetic acid (10 mL), stirred at 0° C., was added tert-butyl mesitylsulfonyloxycarbamate (6.50 g, 20.6 mmol), and the mixture was stirred at 0° C. for 30 min. The mixture was poured into ice-water (10 mL). A white precipitate was formed, which was filtered and collected. The white precipitate was dissolved in DCM (20 mL), and dried with Na2SO4. To the DCM solution was added 1,6-naphthyridin-5-amine (1.0 g, 6.88 mmol), and the mixture was stirred at room temperature for 4 h. The solvent was removed under reduced pressure and the residue was washed with Et2O (3×15 mL). The yellow solid obtained was used in the next step without further purification (3.30 g). ESI MS: m/z 161 [M+H]+.

1. customA white precipitate was formed
2. filtrationwhich was filtered
3. customcollected
4. dissolutionThe white precipitate was dissolved in DCM (20 mL)
5. dry with materialdried with Na2SO4
6. stirringthe mixture was stirred at room temperature for 4 h
7. customThe solvent was removed under reduced pressure
8. washthe residue was washed with Et2O (3×15 mL)
9. customThe yellow solid obtained
10. customwas used in the next step without further purification (3.30 g)