N-bromobutanimide → Methyl 4-(Bromomethyl)-2-tert-butylthiazole-5-carboxylate

HRID 1772154Notes

Reaction equation

HRID 1772154 reaction equation
[Br:1]C1C(C)=C(NCC2C=C(C(C)(C)C)SC=2C(O)=O)C=CC=1.[CH3:23][C:24]1[N:25]=[C:26]([C:33]([CH3:36])([CH3:35])[CH3:34])[S:27][C:28]=1[C:29]([O:31][CH3:32])=[O:30].BrN1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:23][C:24]1[N:25]=[C:26]([C:33]([CH3:36])([CH3:35])[CH3:34])[S:27][C:28]=1[C:29]([O:31][CH3:32])=[O:30]

Participants

5

Reactant 3

HCID 67184N-bromobutanimideHCID 59734470Methyl 4-methyl-2-tert-butylthiazole-5-carboxylateHCID 866979323-((3-Bromo-2-methylphenylamino)methyl)-5-tert-butylthiophene-2-carboxylic Acid

Product 1

HCID 66610676Methyl 4-(Bromomethyl)-2-tert-butylthiazole-5-carboxylate

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Using the same general procedure as described for the preparation of 102e, reaction of methyl 4-methyl-2-tert-butylthiazole-5-carboxylate with N-bromo-succinimide in carbon tetrachloride afforded 125a.

Sources & evidence

ORD record
ord-bd38f8fb59d04dec882a49780967104f
Source dataset
uspto-grants-2016_02
Patent number
US09249123B2

Reaction notes

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