5,7-dichloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine → tert-butyl-N-(1-{[6-(5-chloropyridine-2-amido)-4-{1,3-dimethyl-1H-pyrazolo-[4,3-d]pyrimidin-7-yl}pyridin-2-yl]carbamoyl}ethyl)-N-methylcarbamate

HRID 1772165Notes

Reaction equation

HRID 1772165 reaction equation
[C:1]([O:5][C:6]([N:8]([CH3:33])[CH:9]([CH3:32])[C:10]([NH:12][C:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[C:15]([NH:22][C:23]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=2)=[O:24])[N:14]=1)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:35]1[N:36]=[C:37](Cl)[C:38]2[N:43]([CH3:44])[N:42]=[C:41]([CH3:45])[C:39]=2[N:40]=1>>[C:1]([O:5][C:6](=[O:7])[N:8]([CH:9]([C:10](=[O:11])[NH:12][C:13]1[CH:18]=[C:17]([C:37]2[C:38]3[N:43]([CH3:44])[N:42]=[C:41]([CH3:45])[C:39]=3[N:40]=[CH:35][N:36]=2)[CH:16]=[C:15]([NH:22][C:23]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=2)=[O:24])[N:14]=1)[CH3:32])[CH3:33])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 582224795,7-dichloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidineHCID 123364653HCID 123364653, compound

Product 1

HCID 117914850tert-butyl-N-(1-{[6-(5-chloropyridine-2-amido)-4-{1,3-dimethyl-1H-pyrazolo-[4,3-d]pyrimidin-7-yl}pyridin-2-yl]carbamoyl}ethyl)-N-methylcarbamate

Procedure

K63a is prepared analogously from D1 utilizing 5,7-dichloro-1,3-dimethyl-1H-pyrazolo-[4,3-d]pyrimidine:

Sources & evidence

ORD record
ord-c88ffc74485344209964003d8ada3fa4
Source dataset
uspto-grants-2016_02
Patent number
US09249151B2

Reaction notes

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