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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1772165Generated: October 26, 2026

5,7-dichloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine → tert-butyl-N-(1-{[6-(5-chloropyridine-2-amido)-4-{1,3-dimethyl-1H-pyrazolo-[4,3-d]pyrimidin-7-yl}pyridin-2-yl]carbamoyl}ethyl)-N-methylcarbamate

https://huagongshe.com/reaction/1772165

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5,7-dichloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidineHCID 58222479—
ReactantHCID 123364653HCID 123364653—
Producttert-butyl-N-(1-{[6-(5-chloropyridine-2-amido)-4-{1,3-dimethyl-1H-pyrazolo-[4,3-d]pyrimidin-7-yl}pyridin-2-yl]carbamoyl}ethyl)-N-methylcarbamateHCID 117914850—

Reaction Steps

K63a is prepared analogously from D1 utilizing 5,7-dichloro-1,3-dimethyl-1H-pyrazolo-[4,3-d]pyrimidine:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09249151B2
Source datasetuspto-grants-2016_02
ORD IDord-c88ffc74485344209964003d8ada3fa4
Source noteuspto-grants-2016_02