Hydrochloric Acid → HCID 86719468, compound

HRID 1772206Notes

Reaction equation

HRID 1772206 reaction equation
[ClH:1].[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([N:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)[CH:7]=[CH:6]2>CO>[NH2:16][CH2:15][CH2:14][N:13]([CH2:18][CH2:17][Cl:1])[C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([Cl:2])[CH:4]=2)[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58906309Tert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylate

Product 1

HCID 86719468HCID 86719468, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl (gas) was transferred into a solution of tert-butyl 4-(6-chloro quinolin-2-yl)piperazine-1-carboxylate (1.6 g, 4.6 mmol) in methanol (40 ml) at room temperature with stirring for 1 hour and then concentrated under vacuum to afford N-(2-aminoethyl)-6-chloro-N-(2-chloroethyl)quinolin-2-amine as a white solid (1.1 g, 84%). (ES, m/z): [M+H]+ 248

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-31c7f2b56d484c74b73e5861d8844ff3
Source dataset
uspto-grants-2016_02
Patent number
US09249102B2

Reaction notes

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