Trimethylsilyl iodide → HCID 67501441, compound

HRID 1772305Notes

Reaction equation

HRID 1772305 reaction equation
[Na:1].N1(C(C[C@H](CO)OCP(O)(O)=O)=O)C=C(C)C(=O)NC1=O.[N:23]1([C:31]([CH2:33][C@H:34]([CH2:47][OH:48])[O:35][CH2:36][P:37]([O:43]C(C)C)([O:39]C(C)C)=[O:38])=[O:32])[CH:30]=[CH:29][C:27]([NH2:28])=[N:26][C:24]1=[O:25].I[Si](C)(C)C>>[Na:1].[N:23]1([C:31]([CH2:33][C@H:34]([CH2:47][OH:48])[O:35][CH2:36][P:37]([OH:39])([OH:43])=[O:38])=[O:32])[CH:30]=[CH:29][C:27]([NH2:28])=[N:26][C:24]1=[O:25]

Participants

4

Reactant 3

HCID 85247Trimethylsilyl iodideHCID 11395197HCID 11395197, compoundHCID 66781128HCID 66781128, compound

Product 1

HCID 67501441HCID 67501441, compoundYield 73%

Procedure

This compound was prepared as described for 3f, using 22 (200 mg, 0.53 mmol) as a starting material and iodotrimethysilane (0.6 mL, 4.2 mmol). Compound 3h (130 mg, 0.38 mmol) was obtained as a colorless solid, in 73% yield, which was characterized as follows:

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5220f0fab1b64a7a975f07df73e9d499
Source dataset
uspto-grants-2016_02
Patent number
US09249177B2

Reaction notes

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